Lamina Propria as Regulatory T Cells in HumanbrightCD 25 + CD 4
نویسندگان
چکیده
منابع مشابه
A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis.
In this study, we investigated the role of c-Maf, a transcription factor known to induce IL-4 production, in inflammatory bowel diseases and experimental colitis. Although Crohn's disease (CD) is associated with low IL-4 production by T-bet-expressing Th1 cells in the lamina propria, surprisingly a higher expression of c-Maf in these cells was found as compared with control patients. The releva...
متن کاملSuppressive Mechanisms Induced by Tregs in Celiac Disease
Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4+ T cells wit...
متن کاملImmunoregulation in celiac disease
Celiac Disease (CD) is a T-cell mediated immune disease, in which gluten-derived peptides activate lamina propria effector CD4+ T cells. While these effector T cell subsets produce proinflammatory cytokines, which cause substantial tissue injury in vivo in CD, recent data suggest that additional subsets of CD4+ T cells exist with suppressor functions. These subsets include type 1 regulatory T c...
متن کاملPhenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.
CCL25/CCR9 chemokine ligand/receptor pair has been reported to play an important role in small bowel (SB) immunity and inflammation. We have previously reported an aberrant SB expression of CCL25 in Crohn's disease (CD) and an increased frequency of CCR9(+) T cells in the peripheral blood of patients with SB inflammatory diseases such as CD and celiac disease. In this study, we have characteriz...
متن کاملP-3: Effects of Increased Mast Cells Number-Induced by Sulpiride Atipycal Antipsychotic Drug on Sertoli Cells and Sperm Production in Adult Male Mice
Background: Male infertility is a widespread problem and increased number of mast cells-induced by some drugs like sulpiride atipycal antipsychotic drug, ara described in the testis of males, exhibiting impaired sper-matogenesis and fertility disorders. In this study number of mast cells and sertoli cells, thickness of seminiferous tubule’s lamina propria and sperm concentration and viability i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004